Lyase, citrate
Citrate Lyase
CAS: 9012-83-3
Molecular Formula:
Lyase, citrate - Names and Identifiers
Lyase, citrate - Physico-chemical Properties
| Appearance | lyophilized powder |
| Storage Condition | 2-8°C |
| Use | Application cardiolipin antigen is an ATP-dependent central metabolic enzyme responsible for catalyzing the conversion of citric acid and coenzyme A(CoA) to oxaloacetate and acetyl-CoA, respectively. Acetyl-CoA is essential for biochemical processes such as fatty acid metabolism, cholesterol biosynthesis, protein acetylation and isopentylation. Since the proliferation of many cancer cells depends on the activity of ACLY, ACLY is an important target for the action of anticancer drugs. In addition, ACLY is also a target for anti-dyslipidemia and hepatic steatosis. |
Lyase, citrate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3 |
Lyase, citrate - Uses and methods of synthesis
Overview
heart lipid antigen (ACL,ATP-citrate lyase) can catalyze citric acid and coenzyme A(CoA) into acetyl CoA and oxaloacetate, while a large amount of ATP is hydrolyzed, provide energy for other metabolic pathways. Cardiolipin antigen is a key enzyme in fatty acid biosynthesis and sugar metabolism. Its substrates (citric acid, CoA) and products (acetyl CoA) are key intermediates in sugar metabolism, and can be used as a substrate for fatty acid synthesis; In plants, it is composed of two subunits, mainly in the cytoplasm and chloroplast, and plays a bridge role in the pathway of sugar metabolism and fatty acid metabolism.
physiological role
cardiolipin antigen is a cytoplasmic enzyme that catalyzes the synthesis of acetyl-CoA. It catalyzes coenzyme A and citric acid to produce acetyl-CoA and oxaloacetate, while ATP is hydrolyzed to ADP to release energy. Acetyl-CoA is involved in the synthesis of some important biological substances such as fat and cholesterol, and the protein modification in the acetylation reaction also requires the participation of acetyl-CoA.
Last Update：2024-04-09 22:09:11
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Product Name: Citrate Lyase Visit Supplier Webpage Request for quotationCAS: 9012-83-3
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